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S-Acetyl L-Glutathione is the most effective glutathione variant currently on the market. Glutathione is one of the most potent antioxidants that is naturally produced by the body (and the only one that is intracellular) and it has been shown to neutralize free radicals, detoxify the liver, and to improve the functioning of the immune system. After age 45, the body begins to produce less and less Glutathione and supplementing it becomes an attractive idea.
Unfortunately, most Glutathione supplements have nearly no bioavailability, as the molecule breaks down rapidly after oral ingestion. S-Acetyl L-Glutathione is an altered form with an attached acetyl function group. This greatly improves its ability to remain intact in the gut and allows a greater concentration to be absorbed into the bloodstream where it can take effect.
The recommended dosage of S-Acetyl L-Glutathione is 1-2 100 mg capsule per day. While taking a higher dosage is unlikely to be dangerous, 100 - 200 mg is plenty to get sufficient levels. (Exact amount needed will depend how much one gets from dietary sources.
S-Acetyl L-Glutathione is very well tolerated when taken at the recommended dosage and adverse side effects are very rarely reported. Long term supplementation of glutathione has been shown to lower zinc levels.
While some studies have shown that inhaled glutathione can trigger asthma attacks in people suffering from asthma, there is not currently enough evidence to show that this applies to orally ingested glutathione. Asthma sufferers may want to play it safe and avoid using Glutathione supplements.