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Berberine

$ 19.95 (60 x 500 mg Capsules)
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Allergen Notice:

  • Soy Free
  • Gluten Free
  • Non-GMO
  • Vegan


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Berberine Double Pack -- $34.95     Berberine Triple Pack -- $49.95

Benefits

  • SUPPORT CARDIOVASCULAR FUNCTION - Berberine has been shown to have a beneficial effect on glycemic control and lipid profiles.
  • SUPPORTS MENTAL HEALTH - Berberine is a powerful antioxidant shown to prevent oxidative damage in the brain and to reduce peptides that interfere with proper memory function.
  • HELPS LOWER CHOLESTEROL - Berberine has been shown to lower LDL cholesterol and triglyceride levels.
  • MADE IN THE USA - Our Berberine is manufactured right here in the US.

Description

Berberine is an alkaloid extracted from plants with a history of usage in traditional Chinese medicine. It is most commonly used as a supplement for its anti-inflammatory and anti-diabetes properties, and is also used to reduce liver production of glucose.

Recommended Dosage

We recommend that one 500 mg capsule of Berberine be taken between two to four times per day. It is strongly recommended that each capsule of Berberine taken per day be consumed at least 3 hours after the last one, as taking too much at once can increase the likelihood of gastrointestinal side effects.

Berberine should be taken along with or directly after a meal in order to maximize its beneficial effect on blood glucose levels.

Berberine Side Effects

When taken at normal doses Berberine is non-toxic and is usually well tolerated. The most common side effects reported are stomach upset, cramping, and diarrhea. These side effects are more likely to occur if more than 1 capsule is taken at a time.

Berberine should not be combined with any prescription medications without first consulting a physician as serious adverse reactions can occur when it is combined with certain drugs, specifically Phosphodiesterase inhibitors and microlide antibiotics.

Berberine  -   $ 19.95  (60 x 500 mg Capsules)


Berberine Additional Information

Berberine is a bright yellow alkaloid extracted from numerous plants that has been used in traditional Chinese and Ayurvedic medicine. Most commonly found in Indian Barberry, Oregon Grape, Pellondendron amurense, Goldenseal, and Chinese goldthread, Berberine was traditionally used to combat gastrointestinal issues and to support overall health. (1,2,3)

More light has been shed on berberine in recent years, as over a third of 2,800 studies have been published in the last five years. (3) Prior to that, most of the knowledge on berberine was originally based on a 1997 article published in Alternative Medicine Review. While berberine had been known for its traditional uses, this article by Tim Birdsall and Greg Kelly was the first to focus on berberine for antimicrobial and anti-inflammatory uses. (3)

As a dietary supplement, berberine has shown to have positive effects on blood sugar and cholesterol. It works to reduce insulin resistance and can activate the enzyme, Adenosine Monophosphate-Activated Protein Kinase (AMPK). (4) AMPK acts as the body’s central regulator for cell energy and metabolism.

Berberine Benefits

Through AMPK activation, berberine’s primary benefits are its ability to regulate blood sugar and cholesterol levels. (9,10,11,12)

Regulates Blood Sugar:

AMPK acts as a metabolic master switch that decreases insulin resistance and increases the expression of insulin receptors. Berberine has the added effects of regulating blood glucose levels:

  • Delays the breakdown of carbohydrates into simple sugars as part of the regulation process (15)
  • Berberine mimics insulin action of metabolizing glucose (16)
  • Decreases glucose absorption via the intestinal tract (17)
  • Via AMPK activation, berberine promotes adiponectin – the protein hormone responsible for regulating glucose levels (18)
  • Plays a role in glucose transporter 1 (GLUT1) activity which is responsible for the transportation of glucose across the plasma membranes (19)

Improves Cholesterol:

Berberine, and to a lesser extent its metabolites, have shown to decrease LDL, “bad cholesterol” (13,20) By increasing activity of the LDL receptor in the liver via the JNK pathway. (20)

Berberine aids in decreasing LDL levels in blood by regulating LDL receptors (22,23):

  • Hepatocyte nuclear factor 1alpha (HNF1A) is highly expressed in the liver, intestines, and stomach.
  • Protein convertase subtilisin/kexin type 9 (PCSK9) is a gene that regulates the amount of cholesterol in the blood by controlling the number of LDL receptors.

When a mutated HNF1A binds with PCKS9, it inhibits the ability of PCSK9 to control LDL receptors. Berberine acts by inhibiting HNF1A to allow PCKS9 to break down LDL receptors before they reach the cell surface. (22,23)

Via AMPK activation, berberine also inhibits lipid synthesis in hepatocytes, the cell that makes up 70 – 85% of the liver’s mass. (24)

Other than glucose and cholesterol regulation, berberine has shown other benefits that will be discussed further in the “Berberine Research” section that include:

  • Anti-inflammatory properties (25)
  • May improve memory and learning (26)
  • Antioxidant in the liver (27)
  • Promotes feelings of well-being (28)

How to Use Berberinw

Berberine is most commonly found as a powdered capsule for supplementation. Berberine should be taken with a meal or shortly before a meal for two reasons. Firstly, there is a blood glucose and lipid spike that comes with eating and berberine can help to combat this. Secondly, the absorption of berberine has previously been questioned, and when taken with food it has shown to absorb more effectively. More recently however, berberine has shown to be well absorbed, but quickly metabolized. (3)

As berberine has a short half-life, it is best to supplement several times over the course of a day rather than take the full dosage at one time.

Berberine Dosage Instructions

The recommended dosage for berberine is between 900mg to 1,500mg per day. The most common recommendation is a 500mg dose with meals, three times a day. Dosages should be spaced at least three hours apart to decrease the risk of side effects.

Half-Life and Duration of Effects

Berberine has a relatively short half-life of approximately 3 hours. Because of this, consistent supplementation of 500mg, three time a day, is recommended.

Berberine Safety and Side Effects

Berberine has been reported to be very safe and well tolerated. If you’re taking any other supplement or medication to control blood sugar, consult with a physician prior to supplementing with berberine to ensure blood sugar remains in the proper range.

Repeated use of berberine has shown to inhibit cytochromes P450. (30) Cytochrome P450 contains the enzymes CYP3A4, CYP2D6, and 2C9. These enzymes are primarily expressed in the liver and are involved in the metabolism of certain drugs and dietary supplements. If you’re currently taking any other drugs or dietary supplements, you should check potential drug interactions as you may need to take lower doses to avoid potentially dangerous effects.

The most commonly reported side effects with berberine are upset stomach, nausea, cramping, or diarrhea. Side effects are more likely to occur if taking more than 500mg per dose. Berberine may lower blood pressure so if you’re currently dealing with low blood pressure, consult with a physician prior to supplementing with berberine.

How Berberine Works

The primary mechanism of berberine is to activate AMPK. (3,4) AMPK induces several other mechanisms that are involved in biological activities throughout the body. AMPK aids to regulate and normalize lipid, glucose, and energy imbalances. Without AMPK regulating catabolic pathways, there can be an imbalance in blood sugar, lipid abnormalities, and energy. (9) An activation of AMPK has been proposed to reduce the need for various medications, as controlling AMPK can control different health issues. (10)

Triggering AMPK activation increases glycolysis, the breakdown of glucose by enzymes. (11) Glycolysis leads to decreased insulin resistance and decreased oxygen respiration. Berberine also increases the expression of insulin receptors and reduces insulin resistance. (12) Combined with the glycolysis, this helps to explain berberine’s ability to improve glucose control. (11)

Berberine acts to reduce cholesterol through a mechanism that is unique from statins. (13) Berberine upregulates lipoprotein receptor (LDLR) expression independent of element binding proteins. By elevating LDLR expression through a post-transcriptional mechanism, berberine is able to stabilize mRNA. Using an oxidative enzyme as a reporter, there was an identification of a proximal section of LDLR mRNA 3’ untranslated region that was responsible for the regulatory effect of berberine. (13)

AMPK regulation may play a role in cardiovascular health. A reduction in AMPK phosphorylation has shown to protect from arrythmia and reduce infarct size. (14)

Berberine can be metabolized into four different metabolites; Berberrubine, Thalifendine, Jatrorrhizine, and Demethyleneberberine. (7,8) While Berberrubine has shown to be the most potent activator of AMPK and LDL receptors upregulation, all four metabolites work on similar mechanisms of berberine but with reduced potency. (7,8)

Outside of mechanisms relating to AMPK activation, berberine has shown to inhibit acetylcholinesterase (ACHe) activity. (10) ACHe is and enzyme responsible for breaking down acetylcholine. Inhibiting ACHe aids to prevent the breakdown of acetylcholine, the neurotransmitter responsible for memory and learning. During this process, glucagon-like peptide (GLP-1) also increases. (10) GLP-1 is an amino acid long peptide hormone that enhances synaptic plasticity and reduces the aggregation of amyloid β protein, preventing the build-up of amyloid plaques in the brain.

Berberine Research

Regulates Blood Sugar (29)

36 individuals with high blood sugar were randomly assigned berberine at 500mg, three times daily. The individuals who were assigned berberine saw significant decreases in hemoglobin A1C, fasting blood glucose, post-meal blood glucose, and plasma triglycerides. A separate study on 48 volunteers saw similar effects in fasting and post-meal blood glucose levels. Additionally, the second study saw a decrease in fasting plasma insulin.

Improves Cholesterol (20)

A group of 40 subjects with moderately high cholesterol levels were administered berberine for 4 weeks. Total cholesterol, LDL, HDL, and triglycerides were all measured prior to and at the conclusion of treatment.

At the conclusion of the study, there were improvements in:

  • Total cholesterol: reduced by 16%
  • LDL: reduced by 20%
  • HDL: increased by 6.6%

This suggests that berberine can be beneficial for improving cholesterol levels.

Anti-Inflammatory Properties (25)

Berberine been used in traditional Chinese medicines for its anti-inflammatory abilities. To study this, a group of mice had their nose inflamed via dust to mimic rhinitis. The mice were then split into groups and either treated with berberine or not treated.

The group of mice administered berberine so improvements in symptom and allergen serum scores. Additionally, there were improvements in GATA-3 and T-bet levels which are associated with inflammatory responses due to allergies.

May Improve Memory and Learning (26)

A study on rats was conducted to determine the effectiveness of berberine against memory impairment. The rats were split into a control group and a group that received 25 – 100mg/kg of berberine twice daily for 30 consecutive days. The rat’s memory was tested via a Morris water maze paradigm.

Choline esterase (ChE) was used a marker for cholinergic function and was significantly increased in the rats administered berberine. Lipid peroxidation and glutathione levels were markers for oxidative stress and significantly decreased during testing. The increase in ChE and decrease in oxidative stress lead to improvements in cognitive performance, memory, and learning.

Antioxidant in the Liver (27)

Rats were introduced to varying hepatotoxic factors and then split into a control group and berberine administration groups. Berberine, at doses of 50mg/kg, 100mg/kg, or 200mg/kg was administered daily for four weeks. The biomarkers used were alanine aminotransferase (ALT), serum aspartate aminotransferase (AST), and hepatic activity of superoxide dismutase (SOD).

Berberine administration lead to a decrease in serum levels of ALT and AST while the activity of SOD was significantly increased. This demonstrates the abilities of berberine to improve liver health through the regulation of the antioxidant system.

Promotes Feelings of Well-Being (28)

A study was conduced on rats to determine the antidepressant-like effect that had been reported with berberine use. Administration of berberine at 5mg/kg saw significant increases in serotonin (between 19-47%) and dopamine (between 31-52%). As serotonin is responsible for feelings of well-being and happiness, and dopamine for motivation, this is thought to be the mechanism behind the antidepressant-like feelings.

Berberine FAQ

Can you use Berberine indefinitely?

Berberine is best to be used in a 6 to 8-week cycle followed by a break.

Is berberine good for the liver?

Berberine has shown to have antioxidant properties for the liver. However, berberine inhibits cytochromes P450 in the liver which may cause drug interactions.

Is berberine a blood thinner?

Although it is not intended to be a blood thinner, berberine has been shown to lower blood pressure. If you’re currently taking any medication to reduce blood pressure you should consult with a physician prior to berberine supplementation.

Does berberine kill parasites?

There is currently a lack of clinical trial evidence to support the theory that berberine can kill intestinal parasites.

Can berberine be taken with probiotics?

Berberine may kill certain probiotic strains and reduce the efficacy of the probiotic supplements.

Is berberine in Turmeric?

Due to their similar colors and anti-inflammatory properties, some people do confuse the two supplements. However, the two are unrelated.

Cited Sources

  1. https://www.sciencedirect.com/science/article/abs/pii/S000629521200500X
  2. https://www.ncbi.nlm.nih.gov/pubmed/20836620
  3. https://www.naturalmedicinejournal.com/journal/2012-12/clinical-applications-berberine
  4. https://examine.com/supplements/berberine/#sources-and-structure
  5. https://nootropicsexpert.com/berberine/
  6. https://selfhacked.com/blog/berberine-19-health-benefits-of-berberine-with-references/
  7. https://translational-medicine.biomedcentral.com/articles/10.1186/1479-5876-9-62
  8. https://www.ncbi.nlm.nih.gov/pubmed/23058107
  9. https://www.ncbi.nlm.nih.gov/pubmed/22798688
  10. https://www.ncbi.nlm.nih.gov/pubmed/19818314
  11. https://www.ncbi.nlm.nih.gov/pubmed/17971514
  12. https://www.ncbi.nlm.nih.gov/pubmed/20036710
  13. https://www.ncbi.nlm.nih.gov/pubmed/15531889
  14. https://www.ncbi.nlm.nih.gov/pubmed/26846272
  15. https://www.ncbi.nlm.nih.gov/pubmed/20229011
  16. https://www.ncbi.nlm.nih.gov/pubmed/20515652
  17. https://www.ncbi.nlm.nih.gov/pubmed/12898419
  18. https://www.ncbi.nlm.nih.gov/pubmed/21536037
  19. https://www.ncbi.nlm.nih.gov/pubmed/21545824
  20. https://www.ncbi.nlm.nih.gov/pubmed/17341006
  21. https://www.ncbi.nlm.nih.gov/pubmed/17767919
  22. https://ghr.nlm.nih.gov/gene/PCSK9
  23. https://www.ncbi.nlm.nih.gov/pubmed/16508037
  24. https://www.ncbi.nlm.nih.gov/pubmed/26275466
  25. https://www.ncbi.nlm.nih.gov/pubmed/21262264
  26. https://www.ncbi.nlm.nih.gov/pubmed/17973934
  27. https://www.ncbi.nlm.nih.gov/pubmed/18585703
  28. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2410097/
  29. https://www.ncbi.nlm.nih.gov/pubmed/21870106
Product ratings
Number of reviews : 42
Average rating : 4.8 /5
   06-26-2019
  5/5
Helped to bring my BS down and keep them down
   06-22-2019
  5/5
Very Good !
   04-26-2019
  5/5
It really helped my A1C
   03-27-2019
  5/5
Great quality, have tried many many different brands and this is by far my favorite! The discounted subscriptions and free shipping aren't bad either!
   02-07-2019
  4/5
Helps
   10-26-2018
  5/5
Berberine has helped with my A1C aling with diet and exercise.
   08-30-2018
  5/5
Best I have had to control my glucose
   07-20-2018
  5/5
I have started new diet supported by berberine, just to give it a try, as my sugar was to high. 8 days later! My fasting sugar is down 11 points ( ! ). Unbelieveable but true. Will continue with berberine. Great supplement. Thank you !
   07-18-2018
  5/5
I love not having to remember to order. And i can always change delivery
   07-05-2018
  5/5
great
   06-25-2018
  5/5
This product has helped me keep my blood sugar in check. And having auto ship helps me make sure I have it on hand when needed
   06-22-2018
  5/5
Good
   05-23-2018
  5/5
I'm having desired results in reducing my A1c and glucose spikes.
   05-12-2018
  5/5
Excellent product and great service
   05-05-2018
  5/5
I can tell a difference, unlike some other brands. Thanks!
   04-18-2018
  5/5
Beats Metformin and a lot less stomach issues
   04-10-2018
  5/5
Very good!
   04-06-2018
  5/5
Great product I highly recommend
   03-10-2018
  4/5
I have been getting better blood sugar readings. Hoping that as I continue to use it the numbers will continue to improve. Metformin gave me terrible going distress. So far more tolerable.
   03-07-2018
  5/5
Does what it's suppose to do
   02-12-2018
  5/5
Excellent
   01-26-2018
  5/5
So much better than medication I was taking
   01-04-2018
  5/5
AM TRYING NOW
   12-14-2017
  5/5
The product is American made, is true to its description and contents, and does what it supposed to. I will continue to get my supplements from Doublewood.
   12-06-2017
  3/5
Takes a little longer than expected to receive order.
   11-20-2017
  5/5
Excellent supplement! Excellent service!
   11-06-2017
  5/5
Excellent
   09-19-2017
  5/5
Knowing that my monthly order is coming allows me to relax and enjoy my continued use of this product!
   09-05-2017
  5/5
Excellent
   06-23-2017
  5/5
It is a good product
   05-20-2017
  5/5
I really love this product. I have been tested and can say with 100% certaintly it improves sugar and glucose
   05-20-2017
  5/5
Actually works. My last blood tests showed A!C was down
   05-10-2017
  3/5
I used this product for a couple weeks, can't really comment on blood support as I discontinued use do to stomach irritation.
   05-10-2017
  5/5
Before I started taking this, I had just been diagnosed with Diabetes Mellitus type 2 and had began diet and exercise, but was extremely hesitant to take Metformin for various reasons most concerning of all being the three other medications I would have to take just to counter the potential side effects of it. While researching to find a natural alternative I came across Berberine and Double Wood Supplements. After trying other glucose lowering products and not having much luck with them, I decided to give this supplement a try due to the great reviews and studies I had read vetting Berberine as a viable natural substitute for Metformin.
   05-06-2017
  5/5
I started to have problems with my sugar levels & didn't want to take a prescription drug. I read up on natural sources to help get it under control & found Berberine. I have been taking it going on 5 months & it has done a pretty good job. I changed the way I eat & have been getting a little more exercise which has helped too. My blood sugar was in the 300s when I started & now it stays down around 100 to 140. Stays pretty consistent from just those changes. Not great but a lot better. Hope this keeps it in pretty good check so I don't need anything from the doc.
   05-04-2017
  4/5
I had been doing a keto plan which I had taken a break from, so I purchased this product in July to help with blood sugar control. Later, I received a free bottle from the seller. I will say that I have not taken it as directed ( 3 to 4 times a day, preferably with meals), but I have taken it at least once, mostly two times per day. It has helped me not to get completely out of control with the carbs which was my hope until I return to my keto plan.
   04-26-2017
  5/5
I cannot use metformin so after lots of reading berberine became the next choice. Works much better for me with zero GI problems (unlike metformin) and also works very well with my system. Looking forward to A1c testing soon to see if its working.
   04-19-2017
  4/5
I started taking Berberine last month as a weight loss aid. The recommended dosage is 3 per day, but I am still only taking one because when I increase, I have definite intestinal issues. That being said, one Berberine per day seems to be helping. I have been logging my food and exercise since January and aim for 1200 calories per day and about 2 - 4 hours of exercise each week. Since the onset of menopause, my metabolism has screeched to a halt and I'm lucky if I loose a pound/week while I can easily gain weight. I lost 3 pounds the first week I took Berberine. Following that week, I went on a two week vacation and didn't diet at all. I didn't gain or lose while on vacation. This week, I'm back to my usual dieting and so far so good. I will post updates as time passes.
   04-18-2017
  5/5
IBS (Irritable Bowel syndrome) has been a pretty big problem for me most of my life. I am already at the point where I had to completely cut out breads and grains. I can’t drink beer anymore which is not great. Even though changing my diet has helped me get it somewhat under control it still bothers me a lot and recently I went on a search for supplements to help out. I started a probiotic regimen right away and also came across a study which said berberine helped IBS.
   04-15-2017
  3/5
Does it work for high Lipoprotein a. I have very high cholesterol. I take high doses of (Atorvastatin 80 mg) and I was told it causes liver damage. I'm very worried because I had a stroke. I was told it was because of my high lipoprotein a. I can't find anything you can take for this problem and I don't want to have another stroke.
   04-13-2017
  5/5
Every year for the past 3 years my cholesterol has been just a tad high. It has come back between 240-245. My doctor gave me some diet tips but didn’t really seem that concerned about it. I am almost 40 and in great shape. I also eat very well, so his tips didn’t really make any difference.
   04-11-2017
  5/5
Have reordered twice since my original order. I choose only the best and this product definitely fits into that category. Berberine is an amazing supplement and finding the best quality is of utmost importance to me. Buying anything of a lesser quality is a waste of money.

* These reviews are the experiences of the individual customers that submitted them, results may differ from person to person.

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