Backed By Science - Rigorously Tested - Free Shipping on Orders $30+

Berberine Supplement

$ 19.95

A plant-derived alkaloid studied for its role in metabolic wellness, glucose metabolism support, and cardiovascular wellness,* with every capsule HPLC-verified for full 500mg potency.
Buy More Save More
Purchase: Subscription

Description

Berberine is a well-researched plant compound in metabolic wellness. It is an alkaloid extracted from Berberis aristata with centuries of use in traditional Chinese and Ayurvedic medicine, and a growing body of modern clinical evidence supporting its role in glucose metabolism, carbohydrate handling, cardiovascular health, and AMPK activation. AMPK, adenosine monophosphate-activated protein kinase, is often described as the body's "metabolic master switch," a cellular energy sensor involved in how the body processes glucose and manages energy balance. Berberine is one of the few plant-derived compounds studied for its ability to activate this pathway in cellular and animal research.*

Double Wood's formula delivers 500mg of berberine HCl per capsule, verified by HPLC (high-performance liquid chromatography) on every batch, the same analytical method used in published clinical research. Independent testing has found that potency varies across the berberine category more than many buyers expect. Our most recent COA confirmed not less than 500mg berberine HCl per capsule, tested by a PJLA-accredited ISO/IEC 17025:2017 laboratory. Every batch tested for purity, potency, heavy metals, and microbial safety. Third-party tests by ISO/IEC 17025 accredited labs. COAs published openly.. The 500mg capsule size is intentional. Clinical research typically uses 900–1,500mg daily in divided doses with meals, and a single 500mg capsule gives you flexibility to find the right serving for your body rather than locking you into a fixed dose.

For a more complete metabolic wellness regimen, Berberine pairs naturally with Citrus Bergamot, which supports healthy lipid metabolism and cardiovascular wellness, addressing both glucose and lipid pillars of metabolic health in a single daily routine.*

Benefits
  • 500mg berberine HCl per capsule, HPLC-verified on every batch, the potency standard used in published clinical research
  • Supports glucose metabolism and metabolic health through AMPK activation, one of the more studied mechanisms in metabolic wellness*
  • Flexible single-capsule serving size, 500, 1,000, or 1,500mg daily, not a fixed dose you can't adjust
  • Supports healthy carbohydrate handling and cardiovascular wellness as part of a consistent daily metabolic routine*
  • Every batch tested. Third-party tests by ISO/IEC 17025 accredited labs. COAs published openly.

Directions & Dosage

Take 1 capsule (500mg) with a meal, 1–3 times daily depending on your needs. Most people start with 1 capsule daily and increase gradually over 1–2 weeks to minimize digestive adjustment. Do not exceed 3 capsules (1,500mg) per day. Taking too much at once can increase the likelihood of adverse effects. Always take with food. If you take prescription medications for blood sugar or cholesterol management, consult your healthcare provider before adding berberine to your regimen.

The Science Behind Berberine HCl (from Berberis aristata)

AMPK activation – the metabolic mechanism. Cellular and animal studies. Extensive laboratory and animal studies show that berberine activates AMP-activated protein kinase (AMPK), which acts as a master regulator of cellular energy and metabolism. As noted in foundational research published in Diabetes, "berberine treatment resulted in increased AMP-activated protein kinase (AMPK) activity in 3T3-L1 adipocytes and L6 myotubes." When activated, AMPK supports glucose uptake, promotes fatty acid oxidation, and supports the body's natural mechanisms for maintaining metabolic balance in these preclinical models. This is the same pathway activated by exercise and caloric restriction, part of why berberine has become a well-studied plant compound in the metabolic wellness category.*

Clinical evidence on glucose metabolism. A systematic review and meta-analysis of 14 randomized controlled trials by Dong et al. (2012), published in Evidence-Based Complementary and Alternative Medicine, evaluated berberine supplementation in relation to glucose metabolism in adults with metabolic concerns. This body of research has driven significant scientific interest in berberine's AMPK-mediated mechanisms.*

The potency problem in the berberine category. A 2018 analysis published in the Journal of Dietary Supplements found that 9 of 15 commercially available berberine supplements in the U.S. did not meet pharmacopeial potency standards. ConsumerLab has reported similar findings. We verify potency by HPLC on every batch, with the COA publicly available.

View Latest Test Results

Third-party tested for quality and purity

This production lot was tested for ingredient potency, disintegration, weight variation, heavy metals, and microbial quality.

Test Claim or Limit Result
Potency
Berberine HCl 500 mg 600 mg
Physical Testing
Disintegration USP <2040> Current Passes
Weight Variation USP <2091> Current Passes
Heavy Metals
Lead Not more than 0.5 mcg/daily dose 0.002 mcg/1 capsule
Mercury Not more than 0.3 mcg/daily dose Not Detected
Arsenic Not more than 10 mcg/daily dose Not Detected
Cadmium Not more than 4.1 mcg/daily dose Not Detected
Microbial Testing
Total Bacterial Count Not more than 10,000 CFU/g <10 CFU/g
Total Mold & Yeast Count Not more than 1,000 CFU/g <10 CFU/g
E. coli Negative Absent
Salmonella/Shigella Negative Absent

Lot: 2601-22Manufactured: 03/2026

Lab: Brand International

View Certificate of Analysis (PDF)

See the original Certificate of Analysis for complete testing details, methods, and laboratory documentation.
View Certificate of Analysis View Third Party Test Results
Identity, potency, and contaminants verified per batch Identity, potency, and contaminants verified per batch
Manufactured in an FDA-registered cGMP facility Manufactured in an FDA-registered cGMP facility
Manufactured in the USA from Globally Sourced Materials Manufactured in the USA from Globally Sourced Materials

Benefits

  • Supports Cardiovascular Function: Berberine has been shown to support healthy cardiovascular function.
  • Supports Cognitive Function: Berberine is a powerful antioxidant shown to support healthy cognitive function.
Benefits

Berberine HCl (from Berberis aristata)

Berberine is a quaternary ammonium alkaloid found in the roots, bark, and stems of Berberis aristata and related plants. Double Wood uses berberine in its HCl (hydrochloride) salt form, which improves stability and is the form used in the majority of published clinical research. Each capsule delivers 500mg of berberine HCl, verified by HPLC against a berberine reference standard. This is the same method used in peer-reviewed research and the only reliable way to confirm berberine potency in a finished product. Every batch tested for purity, potency, heavy metals, and microbial safety. Third-party tests by ISO/IEC 17025 accredited labs. COAs published openly.

Berberine HCl (from Berberis aristata)

What Customers Are Saying

Reviews

"Keeping customers informed about their delivery and being proactive in reaching out to customers. Excellent customer service. It's obvious you're in the business of caring for people. Thank you!"

Sonia B.

"Very pleased with the service, from placing my order to receiving it. Painless, simple, and quick."

Craig V.

"Doublewood has consistent quality shipping, great product introductions, and tracks previous orders, and provides incentives for frequent customers. Products are single ingredient supplements, for optimal dosage. Great source for unique supplements."

John T.

See All Reviews
Reviews
Supplement Facts

Pairs well with

Powerful alone, stronger together. Berberine Supplement delivers targeted support on its own, but combining it with complementary ingredients can help create a more holistic and balanced approach to wellness.

  • Vitamin B Complex Drops

    Liquid Vitamin B Complex: energize your daily routine with essential B vitamins for optimal well-being and vitality.

  • Magnesium Glycinate Supplement

    Magnesium Glycinate promotes relaxation and supports overall wellness, making it a great addition to your daily routine.

Frequently Asked Questions

What makes berberine one of the most researched metabolic supplements available?

Berberine's research profile is unusually strong for a plant-derived compound. It has been studied for its role in activating AMPK, a cellular energy sensor involved in glucose uptake, fatty acid metabolism, and energy balance, through a mechanism examined in cellular, animal, and human research. The breadth of the evidence, combined with its long history of use in traditional medicine, makes berberine one of the most well-documented metabolic wellness ingredients available without a prescription.*

What is AMPK and why does berberine's activation of it matter?

AMPK (adenosine monophosphate-activated protein kinase) is often described as a metabolic master switch, a cellular enzyme that senses energy status and helps regulate how the body processes glucose and manages fat. Extensive laboratory and animal studies show that berberine activates AMPK. When activated, AMPK supports glucose uptake in muscle cells, promotes fat utilization, and supports the liver's role in glucose regulation. Berberine is one of the few plant-derived compounds with well-documented AMPK-activating properties in preclinical research, which is the mechanistic foundation for most of its metabolic research.*

How should I approach my daily berberine serving?

Clinical research typically uses 900–1,500mg of berberine daily, split across meals in 2–3 doses. Splitting servings with meals is commonly used for tolerance and consistency. Double Wood's 500mg capsule is sized to support this approach. Start with 1 capsule daily with your largest meal, increase to 2 capsules with 2 meals after 1–2 weeks if well tolerated, and increase to 3 capsules with meals if desired. Starting low and increasing gradually is the best way to minimize GI adjustment.

What supplements pair well with Berberine?

Citrus Bergamot is the most complementary pairing for those building a metabolic wellness routine. Berberine supports healthy blood sugar within the normal range, while Citrus Bergamot supports healthy cholesterol within the normal range, together covering both key pillars of metabolic health in a single daily regimen.*

Why does potency verification matter so much for berberine specifically?

Potency can vary across the berberine category, which is why verification matters. A 2018 analysis published in the Journal of Dietary Supplements found that 9 of 15 U.S. berberine products did not meet potency standards. We verify berberine content by HPLC on every batch, the analytical method used in published research, with the COA publicly available on this page.

Is berberine safe to take with other medications?

Berberine can have additive effects on glucose metabolism and may interact with medications used to manage blood sugar, including metformin. If you take prescription medications for blood sugar, cholesterol, or cardiovascular health, consult your healthcare provider before starting berberine. Berberine should not be used during pregnancy. Those with liver conditions should also consult their provider, as berberine is metabolized hepatically.

How long does it take to notice the effects of berberine?

Berberine's effects build with consistent daily use rather than appearing immediately. Published research has observed meaningful changes in metabolic markers, including HbA1c, over 8 to 12 weeks of consistent daily supplementation. It is not a supplement with an immediately noticeable effect, as a stimulant might. The most reliable approach is consistent daily use with meals over a sustained period, combined with the dietary and lifestyle habits that support metabolic wellness.*

Overall rating: 4.839161 / 5 from 143 reviews.

AI Generated Review Summary

Customers praise the Berberine Supplement for its excellent pricing, quality, and effectiveness in managing blood sugar and cholesterol levels. The supplement is also noted for its soy-free, gluten-free, non-GMO, and vegan attributes.

Summary topics

  • Pricing (9%): Customers raved about the excellent pricing of the product, with many mentioning it as a great deal.
  • Supplement Effectiveness (6%): It was reported by customers that this supplement has slightly lowered their A1C and cholesterol levels.
  • Berberine Taste and Effectiveness (14%): It was noted by customers that they love berberine for its taste and effectiveness in managing blood sugar.
  • Product Quality (9%): It was highlighted by customers that the quality of the products is excellent and top-notch.

Review topics: ["quality","results","stomach","issues","formula","dose","value","shipping","price","berberine","order","supplement","blood sugar","wood","work","brand","effect","service","mind","difference","subscription"].

Review highlights

  • "I'm impressed with the quality and price." — Laura M.
  • "The discounted subscriptions and free shipping aren't bad either!" — Anonymous
  • "The price is great and the product is good!" — Anonymous

Reviews

"Well I really don’t see any difference."

— Denise (4/5)

"Your supplements are amazing and the time at which I receive them is also great!!"

— Chris (5/5)

I tried another product when

"I tried another product when I forgot to reorder from doublewood. It didn't work as well. I really like and trust doublewood supplements. Also the customer service is outstanding."

— Martina C. (5/5)

"Double Wood, great products."

— Amy (5/5)

"Great service and products!"

— Irene (5/5)

Good Enough -Especially For The Price

"Works great. Especially, if you are on a budget."

— Rory P. (4/5)

A1C was 6. 8. Started Berberine

"A1C was 6. 8. Started Berberine on the advice of my doctor. After 3 months, A1C of 6. 3. Will definitely keep taking."

— jeff m. (5/5)

Berberine

"Stomach"

— Fred M. (5/5)

Berberine is a game changer!

"I wanted to share an honest review for anyone really looking into Berberine and trying to find something that actually works without upsetting your system. I’ve tried other Berberine supplements before, but many of them included green tea or caffeine, which completely irritated my stomach. That just didn’t work for me. Double Wood’s formula has been much more gentle, which was a huge relief. I currently take their Inositol and Berberine together, and I’ve noticed a real difference—especially with cravings. I’m on a GLP-1 and was still struggling with sweet cravings and nighttime hunger, but within about three days of taking this, those cravings noticeably decreased. I follow the recommended dose (one per day), and I’m planning to get updated labs soon to see how everything looks, especially since my weight has been slower to move even with GLP-1. Of course, diet and exercise still matter, but this supplement feels like it’s actually supporting those efforts instead of working against them. Overall, Double Wood has been one of the most reliable brands I’ve used. Their products are consistent, effective, and easy on my stomach—which is everything for me."

— Lenora C. (5/5)

complete line of products

"This one seems to do its job but many of the other ones seem to have lost strength or something. Colors have changed and effects are just not there anymore."

— scott s. (4/5)

Q&A

What plants are used to make your berberine? Thank you Fain
Our Berberine is berberis aristata. We hope this helps.

Berberine Supplement

From

$ 19.95

Primary Benefit

Metabolism

Other Benefits

Heart & Vessels, Liver Health

Product Form

Capsule
View product
Double Wood Supplements BBB Business Review