Skip to main content

CDP Choline

$ 19.95 (60 x 300 mg Capsules)
cdp choline
cdp choline ingredients
cdp choline supplement

View Certificate of Analysis

View Third Party Test Results

Allergen Notice:

  • Soy Free
  • Gluten Free
  • Non-GMO

Buy Multiple Bottles and Save!

CDP Choline Double Pack -- $34.95     CDP Choline Triple Pack -- $49.95


  • INCREASE CHOLINE LEVELS - CDP Choline is a potent and cost effective way to increase acetylcholine levels.
  • ENHANCE MEMORY - Learn information with greater ease, retain more of what you learn, and recall memories quicker.
  • BOOST COGNITIVE FUNCTION - Improves working memory, motivation, and problem solving ability
  • MADE IN THE USA - Our CDP Choline is manufactured right here in the US


CDP Choline is a potent and cost effective way to supplement your choline intake. Choline is a water soluble nutrient which acts as a precursor to the neurotransmitter acetylcholine. Acetylcholine plays an important role in many cognitive processes including memory, intelligence, and mood.

Recommended Dosage

A conservative dosage estimate when taking CDP Choline as a general nootropic supplement is to take 1-2 300mg capsules in the morning. This dosage can be repeated in the afternoon if necessary. While there is no real consensus on an optimal dose, and no health organizations have provided any dosage guidelines it is generally not recommended to exceed a dosage of 1200 mg per day.

CDP Choline Side Effects

When used at moderate doses of less than 1200 mg per day, and less than 600 mg taken at any one time CDP Choline is extremely well tolerated and rarely are adverse side effects present. Some people have reported minor side effects including heartburn, insomnia, and dizziness. Consult your physician before taking this product.

CDP Choline  -   $ 19.95  (60 x 300 mg Capsules)

Want to learn more about CDP Choline?

CDP Choline Additional Information

CDP Choline, also known as Citicoline, is a choline supplement used primarily for memory formation, learning ability, and overall cognitive function. (1,2,3,4) CDP choline acts very similarly as a prodrug would for choline and uridine. (1,3) CDP choline is one of the most bioavailable sources of choline via oral ingestion.

CDP choline is unique as a source of choline as once it’s digested, it separates into cytidine and choline. Choline is present in all cells in the human body but supplementing as a nootropic it has shown to have positive effects on cholinergic brain function. (1,2,3,4)

Although Citicoline is unregulated in the United States and is sold over the counter as a dietary supplement, there are parts of the EU and Brazil where CDP choline is only available with a prescription. (4)

CDP Choline Benefits

One of the primary benefits of CDP choline is in increase in acetylcholine in the brain. Acetylcholine is a neurotransmitter that sends signals to different cells throughout the body. CDP Choline also works to potentiate other nootropics which is why it’s commonly stacked with racetam class nootropics.

CDP Choline has been shown in studies to impact the levels of catecholamine neurotransmitters. (4) Catecholamine neurotransmitters include dopamine, adrenaline, and norepinephrine.

Additionally, CDP choline is a precursor that is essential for the synthesis of phosphatidylcholine. Phosphatidylcholine is a cell membrane component that is rapidly degraded when there is a lack of blood flow to the brain. CDP choline aids to protect these cell membranes and accelerates the resynthesis of phospholipids. As this is an attribute of some strokes, it has been shown that CDP choline can be administered immediately following a stroke to aid in recovery. (11)

Many other benefits occur as a factor of the production of choline and they can be found in “Research and Scientific Studies” section. These benefits include but are not limited to:

  • Improvement of memory and learning (5)
  • Counteracts the effects of again on the brain (6)
  • Slows unwanted changes to the brain (8)
  • Enhanced nerve factor growth in the brain (7)
  • Increased growth hormone secretion (9)
  • Improves cognitive performance of individuals with Alzheimer’s (10)

How to Use CDP Choline

CDP Choline is most commonly found as a powdered capsule that ranges from 100mg per capsule to 500mg per capsule. CDP Choline is water-soluble and therefore is best taken on an empty stomach. Since this is the case, generally CDP Choline should be used in the morning. However, depending on desired effect, subsequent doses of CDP can be taken 8 to 12 hours later. Taken orally, up to 95% of the dosage is absorbed by the body. (4)

CDP Choline Dosage Guidelines

Dosages for CDP Choline may be dependent upon what effects an individual would like to see from the supplement. A general dosage is recommended at 300 mg to 600mg in the morning. A dosage of up to 1,000mg is fine but recommended to be split across two dosages, 8 to 12 hours apart. (1,2,3,4)

Some benefits of CDP Choline, increased bioenergetics or attention-promotion are more prevalently responsive at a lower dosage. However, there are other benefits such as decreased appetite that are more responsive at a higher dosage. (1)

Over different scientific studies dosages have ranged from 500mg to 2,000mg per day. One study showed that a dosage of 4,000mg had no measurable difference from a dosage of 2,000mg indicating little to no value in taking the higher dosage. (4) If using CDP Choline as part of a nootropic stack, a dosage of 300mg once or twice per day is recommended. (4)

Half-life and Duration of Effects

CDP Choline typically begins to work 2 to 3 hours after oral administration at a dose of 5600mg. CDP Choline’s half-life has been reported to be anywhere from 55 to 75 hours. (1)

CDP Choline Safety and Side Effects

CDP Choline is considered very safe and well tolerated. Although studies have shown that there is no toxicity up to 4,000mg, no more than 1,200mg is recommended for a day to avoid adverse side effects. (4) Prior to taking any supplement, you should always consult a physician. It is not recommended to take CDP Choline and operate heavy machinery until your familiar with how different dosages effect you.

While adverse side effects are rare, the most commonly reported side effects are insomnia, nausea, dizziness, or chest pains.

How CDP Choline Works

CDP Choline is hydrolyzed in the intestines where it’s broken down into it’s two components, cytidine and choline. It then crosses the blood-brain barrier and disperses throughout the body. (4) Cytidine is a component of Ribonucleic acid (RNA). This is involved in the coding and regulation of genes for the human body. Once cytidine reaches the brain, it converts to uridine which acts to repair cell membranes and maintain neuron integrity. (2)

Choline is a precursor to the neurotransmitter acetylcholine (ACh). CDP Choline aids in increasing acetylcholine levels in the brain which increases the electrical signaling between neurons.

CDP Choline also aids in increasing the effects of other nootropics when stacked together. CDP Choline is most effective with the racetam class nootropics where it gives greater potential for memory boosting while avoiding the headaches generally associated with these nootropics. (4)

Additionally, CDP Choline increases levels of Adenosine triphosphate (ATP) in brain cells. ATP is a coenzyme that provides the energy source for brain cells.

CDP Choline Research and Studies

Citicoline Improves Memory and Learning (5)

A scientific study was conducted on rats, where some were normal, and some were spontaneously hypertensive. Hypertension is considered a risk factor for the development of cognitive disorders. This is due to the negative effects on both cerebral circulation and blood flow.

Both sets of rats were tested on short-term memory, five choice reaction time, visual attention processes, and spatial learning and mnemonic capabilities. Half of the rats from both groups were randomly selected to be given doses of uridine and choline (two components that CDP Choline breaks down to).

It was determined that the hypersensitive rats had their scores normalized when administered the choline while the rats from the “normal” group had improvements as well.

Enhanced Nerve Factor Growth in the Brain (7)

Separate tests were conducted on rats of varying ages in which they were given different doses and sources of choline. These tests were conducted over six months to see how the brains of the different aged rats would react.

Both tests were able to demonstrate that the number of silver grains in the older rats were diminished as the cholinergic receptors were introduced to the hippocampus. It also demonstrated that these grains/fibers did not develop as quickly in the younger rats.

An additional study was conducted where choline was administered at 100mg a day for six months. This study was conducted on rats aged 24 months which is considered generally old for a rat. In rats, the cerebellar cortex contains amounts of Nerve Growth Factor (NGF). Along with NGF receptors, these are sensitive to aging. The addition of the choline suggests that it may increase the expression of NGF receptors.

Increases Growth Hormone Secretion (9)

As individuals age, growth hormone (GH) secretion decreases. This may be in-part due to a decrease in growth hormone-release hormone (GHRH). One study was conducted on both young and old human volunteers where they were given GHRH. Half of this volunteer group was also given a form of choline.

As expected, GH secretion was greater with the younger volunteers. However, the groups given the choline with the GHRH showed increased levels of GH secretion compared to their same-aged counterparts only given the GHRH. Additionally, the older volunteers saw more pronounced levels of GH secretion with the addition of the choline. This can conclude that increases in choline can increase GH secretion.

Improves Cognitive Performance of Individuals with Alzheimer’s (10)

It is important to note that not enough clinical testing has been completed to definitively state the effectiveness of choline on patients with dementia or Alzheimer’s. The studies being discussed are only a starting point for these conversations.

126 patients with mild to moderate senile dementia of Alzheimer’s type (SDAT) were tested by means of behavioral scales and psychometric testing. These patients were either administered a choline pre-cursor (Alpha-GPC) acetyl-l-carnitine (ST200), a quaternary ammonium compound. It was found that the patients who were administered Alpha-GPC showed significant improvement in testing.

CDP Choline FAQ

Is CDP Choline safe?

CDP Choline supplementation has been found to be very safe and non-toxic.

How does choline help the brain?

Choline primarily helps the brain by producing acetylcholine which is a key neurotransmitter for mental focus and learning.

Is CDP Choline a stimulant?

CDP Choline does not act as a stimulant.

Does CDP Choline help with weight loss?

Choline has been shown to help lipid metabolism which might encourage body mass reduction, but this is generally found to be more successful in active individuals and should not be used as a weight loss supplement.

Which foods are highest in choline?

Eggs, beef liver, and grass-fed raw dairy are some of the highest sources of choline in food but have been shown to be metabolized by the body and are not as efficient as CDP Choline at supplementing the body.

What causes choline deficiency?

Choline deficiency is generally caused by an individuals’ diet. Most western diets do not have sufficient amounts of choline. However, food with choline is not as effective as choline supplementation as the choline in the food gets metabolized.

Cited Sources

Product ratings
Number of reviews : 20
Average rating : 4.7 /5
Great for recall and mental clarity. Pair it with uridine and fish oil.
It was recommended to me with Bacopa Gold. I can't really tell the difference because i am 77 and at this age there is a natural loss of immediate memory.
Still in review for myself Believe it is more helpful than pharmaceutical
I have dealt with some memory problems since I was given a bad medicine. Since taking CDP Choline I am as sharp as when I was a teen. No more brain freezes.
The auto renew is great, cdp choline you notice a little difference, women need this
Great product
Increase in brain function and mental health
These work for me! I wanted to try choline supplementation to see if it would help alleviate the mental exhaustion and fogginess I was having due to some chronic health issues. I started taking another brand's, Choline Bitartrate, but after taking it for over a month with no noticeable improvements I decided to do more research. I found that CDP Choline is higher quality than Bitartrate, more easily absorbed and utilized by the body, and contains more benefits overall. This CDP Choline supplement is the one I needed and I'm so glad I figured it out! I started taking one each morning and noticed a difference right away! I have more mental alertness and focus and no longer feel run down. I now take 2 each morning and have them auto-shipped monthly.
I heard this can benefit babies while pregnant and have been taking it as it was approved by my OBG. Great customer support and shipping was quick
My memory has improved and no this is not a placebo
I bought this due to recommendations of CDP Choline as a highly bio-available source of choline. My purpose for adding this was to help alleviate some of the tip-of-the-tongue moments when speaking. As I am in management and also teach a class regularly, I need to be at my best cognitively and speech wise. The Double Wood brand had good reviews and the best price so I decided to order a bottle and try it. I take it in the AM along with my other supplements. The effects are subtle but apparent--my thoughts and speech seem to be more synchronized and over-all seem to flow better. I have since ordered my 2nd bottle and plan to keep this a regular part of my regimen. A good purchase!
I had been using another brand of citicoline for a couple of years, and I was satisfied with the results. I ordered this to try it out, and after a couple of weeks I noticed an improvement in cognitive clarity. It has a slightly higher active ingredient content than the product that I had been taking. I will be using the Double Wood brand from now on...
It helps with memory but made the skin on my eyelids blister and made me very thirsty. If you dont have side effects like I did they its good. Everyone is different
First I tried the alpha version from Double Wood after trying the Bitartrate from a local market. Althought it is hard for me to really distinguish the different form, I do find Choline to help me focus and seems to improve memory. Double Wood is packaged well, made in USA, and the capsules are easy to swallow ( unlike the pressed pills from ""other "" sellers. Company seems great, product is pretty good. Only thing with Choline is it seems to stop having effect if taken daily. I use it on days I need a little extra, like a test or new learning activities.
Have just started using it but I have been told this product is the best for the brain and memory. I think I'm a little bit clearer - a tad better memory in just the 4 days I've been taking it.
For a period of one year I had been suffering from cognitive impairment, memory loss, and an inability to focus (due to possibly an ischemic stroke which I have suffered from in the past). I saw a Neurologist who recommended more sleep, less caffeine consumption, and more activity. I think it was great advice however it was not working for me. One day I was looking online for supplements which boost memory when I came across CDP Choline. I ordered a bottle and after a few weeks I felt like myself again. I was able to focus at work and recall things much easier. I take one pill along with a Men's One-A-Day every morning and I no longer worry about being unable to be productive at work or being forgetful as I was before I started taking CDP Choline
I have CFS/ME and have spent thousands on supplements and treatments. I will try anything that may help. Every person is different but this was the first supplement that increased my energy and my cognition. HIGHLY recommended.
Prompt delivery. I especially like the extra 50 mgs over the other brand that I was using previously for the same price. I convinced a friend to make the switch also.

* These reviews are the experiences of the individual customers that submitted them, results may differ from person to person.

Ordering from Canada?

Unfortunately we can't accept credit card payments from non-US credit cards through, but we've been working hard to make our products available in Canada and have a few options for Canadians to order.

Many of our products are available to purchase on, and are currently warehoused in Canada. If the products you're looking for are on, this will be the easiest and quickest way to order.

Alpha GPC


Bacopa Monnieri Extract


CDP Choline


Citrus Bergamot Extract




Huperzine A




Magnesium Threonate


Rhodiola Rosea Extract


S-Acetyl L-Glutathione






Order by Email

Send us an email at with what you'd like to order, and we will send over an invoice from another of our websites that can take international credit card payments. Once the invoice is paid we will ship out your order promptly.