SAVE up to 25% SITEWIDE

Code: WHD2025

What is a Methylated Multivitamin?

What is a Methylated Multivitamin?

Jessica Justh  |

What is a Methylated Multivitamin?

Methylated multivitamins are gaining attention for their bioavailability and potential to support overall health. These supplements are formulated with vitamins in their active, methylated forms, allowing for efficient use by the body. 

For those who have difficulty metabolizing certain nutrients or have genetic variations, such as MTHFR mutations, methylated multivitamins may help support their nutritional needs by providing bioavailable vitamins that do not require additional conversion.


What Does it Mean for a Vitamin to be Methylated?

Methylated vitamins contain a methyl group (-CH3) attached to their structure, allowing them to be used by the body in their active form. This eliminates the need for the body to convert the vitamin into its active form, which is necessary for non-methylated vitamins. 

How Methylation Impacts Vitamin Function

Since methylated vitamins are already in their active forms, they can be beneficial for individuals with compromised methylation pathways, who may have difficulty converting certain vitamins into their usable forms. 

Because of this key characteristic, methylated vitamins support several bodily functions:

  • DNA Synthesis: They contribute to the production and maintenance of DNA, which is essential for cell division and overall health.2

  • Neurotransmitter Support: Methylated vitamins like methylcobalamin and methylfolate are involved in processes that support the production of neurotransmitters such as serotonin, dopamine, and norepinephrine, which are associated with brain function and mood regulation.3

  • Homocysteine Metabolism: Methylated vitamins assist in the conversion of homocysteine, helping to maintain balanced levels within the body.4

Examples of Methylated Vitamins

Not all vitamins can be methylated. It typically applies to B vitamins, with some of the most common being: 

  • Methylfolate: The active form of vitamin B9, which plays a role in processes like DNA synthesis and amino acid metabolism.

  • Methylcobalamin: A form of vitamin B12 that the body can use to support nerve function and red blood cell production.

  • Riboflavin-5-phosphate: A form of vitamin B2 that supports energy production and antioxidant function. 


 

How Do You Know If a Vitamin is Methylated?

Many suppliers highlight these active forms to demonstrate the bioavailability of their products. 

(Insert photo of DW Methylated Multivitamin bottle)

It should be relatively easy to determine if a vitamin is methylated. Simply check the label to look for terms like:

  • Methylfolate or 5-MTHF for folate.

  • Methylcobalamin for vitamin B12.

  • Pyridoxal-5-Phosphate (P-5-P) for vitamin B6.


 

Why Take a Methylated Multivitamin?

Methylated multivitamins may offer several potential benefits, including:

Enhanced Absorption

Methylated vitamins are in their active form, which may support better bioavailability and more immediate use by the body.1 

Support for Energy Levels

Methylated B vitamins are involved in energy production, which may help reduce fatigue and support overall vitality.5

Support for Cognitive Function

These vitamins play a role in producing neurotransmitters that support mood regulation and cognitive functions, potentially promoting memory, concentration, and mental clarity.3 

Cardiovascular Health

Methylated B vitamins may help regulate homocysteine levels, which are important for heart health.4 

Detoxification Support

The supplements support liver function, which may assist with the body's natural detoxification processes.6 

Genetic Considerations

Methylated vitamins may bypass potential genetic variations (like MTHFR mutations) that can impact the body's ability to convert certain vitamins to their active forms.7

Mood Support

Some studies suggest that certain methylated vitamins may support mood and emotional well-being.3 

Potential Benefits of a Methylated Multivitamin for Men

  1. Prostate health: Some methylated multivitamins include ingredients like lycopene, which may help support overall prostate health.

  2. Muscle function: Vitamins D, B6, B12, and zinc, which are commonly found in multivitamins, play a role in muscle function and overall wellness.

  3. Hormonal support: Specific formulations for men may contain certain nutrients to help maintain healthy testosterone levels. 

Potential Benefits of a Methylated Multivitamin for Women

  1. Prenatal nutrition support: Methylated folate plays a role in fetal development and maternal health during pregnancy.

  2. Iron support: Many women's formulas include iron to help meet daily iron needs, particularly for those with higher requirements. 

  3. Bone health: Women's multivitamins often provide calcium and vitamin D, which contribute to bone strength and overall wellness, especially as nutritional needs change with age. 


 

Which Vitamins are Commonly Included in a Methylated Multivitamin?

Methylated multivitamins typically contain a combination of essential vitamins and minerals to provide broad nutritional support, including: 

Methylated B Vitamins

  • Methylfolate (Vitamin B9)

  • Methylcobalamin (Vitamin B12)

  • Pyridoxal-5-phosphate (Vitamin B6) 

  • Riboflavin-5-phosphate (Vitamin B2) 

Other Common Nutrients

  • Vitamin D3

  • Vitamin K2

  • Zinc 

  • Selenium

  • Magnesium

  • Iodine

  • Manganese

  • Chromium

  • Molybdenum

Additional Ingredients in Some Formulations

  • Coenzyme Q10

  • N-Acetylcysteine (NAC)

  • Choline

  • Benfotiamine (a fat-soluble form of Vitamin B1)


 

Frequently Asked Questions (FAQs)

  1. Can I take methylated multivitamins with other supplements or medications?

Dietary supplements may interact with certain medications. It’s recommended to consult a healthcare provider before adding a new supplement to your routine.

  1. Can methylated multivitamins be taken during pregnancy?

Methylated folate and B12 play important roles during pregnancy. However, you should always speak with a healthcare professional to determine the appropriate supplementation for your individual needs while pregnant.

  1. Are there any dietary restrictions when taking methylated multivitamins?

There are no universal dietary restrictions for those taking methylated multivitamins. However, consuming a well-balanced diet can support overall nutrient intake. 


 

Support a Healthy Lifestyle with Double Wood Supplements

Double Wood Supplements offers methylated multivitamins formulated for efficient nutrient absorption. Explore our range of products designed to support energy, cognitive health, and overall wellness.

Visit Double Wood Supplements to find a supplement that fits your nutritional needs.

Citations:

[1] https://www.discovermagazine.com/health/methylated-multivitamins-may-be-easier-to-absorb-for-some-people 

[2] https://pubmed.ncbi.nlm.nih.gov/12163697/ 

[3] https://pmc.ncbi.nlm.nih.gov/articles/PMC3869616/ 

[4] https://pmc.ncbi.nlm.nih.gov/articles/PMC7190578/ 

[5] https://pmc.ncbi.nlm.nih.gov/articles/PMC7019700/ 

[6] https://pmc.ncbi.nlm.nih.gov/articles/PMC4488002/ 

[7] https://pmc.ncbi.nlm.nih.gov/articles/PMC8703276/ 

4 minute read