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Fisetin Supplement

$ 22.95

Fisetin is a powerful antioxidant that supports memory and cognitive health, helping you feel sharp and focused.
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Description

Fisetin occurs naturally in foods such as strawberries, apples, and onions, but only in small amounts. Double Wood sources fisetin from smoke tree (Cotinus coggygria) stems, a naturally concentrated botanical source that makes it possible to provide 100 mg of fisetin per capsule.

Fisetin is best known for its antioxidant and senolytic research. Senolytics are compounds being studied for their potential ability to selectively target senescent cells—aging or damaged cells that have stopped dividing but remain active in the body.

Preclinical research, including a 2018 study involving Mayo Clinic researchers, identified fisetin as the most potent senolytic among ten flavonoids tested. Fisetin has since advanced into Phase 2 human trials, including studies evaluating it in older adults with COVID-19 and patients with sepsis. These trials demonstrate growing clinical interest, but fisetin’s senolytic and healthy-aging benefits have not yet been established in humans. COVID-FISETIN trial, STOP-Sepsis trial

Soy-Free, Gluten-Free, Non-GMO, Vegan

Benefits
  • SENOLYTIC AGENT: Fisetin is classified as a "Senolyitc Agent" meaning it supports your body's ability to clear away damaged or potentially harmful cells
  • HEALTHY AGING SUPPORT: Fisetin helps support healthy aging by promoting cell efficiency
  • POWERFUL POLYPHENOL: Fisetin is a powerful polyphenol which may support organ health, brain health, and mood
  • ROOTED IN QUALITY: Manufactured and Tested in the USA from Globally Sourced Ingredients. Double Wood's Fisetin are manufactured and tested for microbes and heavy metals right here in the USA from Globally Sourced Ingredients. Plus, they are vegetarian,Non-GMO and gluten-free
  • WE BOTTLE WELLNESS: At Double Wood we provide pure, potent supplements that deliver exceptional value, all backed by careful sourcing and rigorous third-party testing

Directions & Dosage

We recommend 100mg per day taken with a meal for ongoing antioxidant and cognitive support. This dose is consistent with amounts used in human observational research

View Latest Test Results

Third-party tested for quality and purity

This production lot was tested for ingredient potency, disintegration, weight variation, heavy metals, and microbial quality.

Test Claim or Limit Result
Potency
Fisetin 100 mg 113.50 mg
Physical Testing
Disintegration USP <2040> Current Passes
Weight Variation USP <2091> Current Passes
Heavy Metals
Lead (Pb) NMT 0.5 mcg/Daily Dose 0.055 mcg /1 capsule
Mercury (Hg) NMT 2.0 mcg/Daily Dose <0.013 mcg/1 capsule
Arsenic (As) NMT 10 mcg/Daily Dose 0.033 mcg/1 Capsule
Cadmium (Cd) NMT 4.1 mcg/Daily Dose <0.007 mcg/1 Capsule
Microbial Testing
Total Bacterial Count NMT 10,000 CFU/gram PASS
Total Mold & Yeast Count NMT 1,000 CFU/gram PASS
E. Coli Negative PASS
Salmonella/Shigella Negative PASS

Lot: 2319801Manufactured: 09/2023

Lab: Nutra Solutions USA

View Certificate of Analysis (PDF)

See the original Certificate of Analysis for complete testing details, methods, and laboratory documentation.
View Certificate of Analysis View Third Party Test Results
Identity, potency, and contaminants verified per batch Identity, potency, and contaminants verified per batch
Manufactured in an FDA-registered cGMP facility Manufactured in an FDA-registered cGMP facility
Manufactured in the USA from Globally Sourced Materials Manufactured in the USA from Globally Sourced Materials

Benefits

  • Senolytic Research: Fisetin is one of the most widely studied naturally occurring compounds in preclinical senolytic research.
  • Antioxidant Support: Fisetin helps support the body’s defenses against oxidative stress.
  • Cognitive Health: Preclinical research suggests that fisetin may support neuronal health and cellular pathways involved in learning and memory.
  • Smoke-Tree Source: Double Wood sources fisetin from Cotinus coggygria to provide a concentrated 100 mg serving per capsule.
  • Healthy Aging Support: Fisetin is studied for its potential role in cellular maintenance, senescent-cell research, and age-related wellness.
Benefits

Fisetin

A plant flavonol found in strawberries and apples. It is recognized in traditional wellness practices and modern nutrition. It is commonly chosen to supports healthy cellular aging pathways and antioxidant defenses.

Fisetin

What Customers Are Saying

Reviews

"Reputation of product and overall delivery and ordering experience has always been a good experience."

Jacqueline P.

"Always fast shipping and great selection no matter what you’re looking for."

Aaron B.

"Double Wood is always my go-to for supplements. Great, effective, clean products and always at a reasonable price."

Jan W.

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Reviews
Supplement Facts

Pairs well with

Powerful alone, stronger together. Fisetin Supplement delivers targeted support on its own, but combining it with complementary ingredients can help create a more holistic and balanced approach to wellness.

  • Spermidine Supplement

    Spermidine is a natural compound that supports cellular health and metabolism, found in foods like peppers and mushrooms.

  • PQQ (Pyrroloquinoline quinone) Supplement

    PQQ supports energy production by enhancing mitochondrial function, helping you feel more energetic and vibrant throughout the day.

Frequently Asked Questions

How much fisetin should I take?

Double Wood provides 100 mg of fisetin per capsule for routine use. Follow the product label and do not exceed 300 mg daily. Higher amounts are being investigated in senolytic research, but these experimental protocols are not established general-use recommendations.

How should I take fisetin?

Take Double Wood Fisetin according to the product label, preferably with a meal for digestive tolerance and consistency. Fisetin has limited water solubility, but human research has not established that dietary fat alone meaningfully improves the absorption of standard fisetin.

What is the difference between daily and pulsed fisetin dosing?

Daily supplementation uses a lower amount taken consistently, while experimental senolytic protocols use larger amounts for a limited number of days followed by time without supplementation.

Double Wood’s labeled serving is intended for routine use and should not exceed 300 mg daily. High-dose pulsed protocols may exceed the labeled amount and should not be attempted without guidance from a qualified healthcare professional.

How may fisetin support memory and brain health?

Preclinical research suggests fisetin may support neuronal health through its antioxidant activity and its influence on ERK/MAPK signaling, a pathway involved in learning, memory, and synaptic function. In one mouse study, fisetin maintained learning and memory performance while increasing ERK activity and reducing markers of oxidative stress and inflammation. Human cognitive benefits have not yet been established.

Why does Double Wood use smoke-tree fisetin?

Fisetin occurs naturally in foods such as strawberries and apples, but generally only in small amounts. Double Wood sources fisetin from the smoke tree, Cotinus coggygria, to provide a concentrated and clearly disclosed 100 mg serving per capsule.

How does Double Wood Fisetin compare with enhanced-bioavailability fisetin?

Double Wood provides 100 mg of standard fisetin per capsule. Some other products use delivery systems designed to increase the amount of fisetin absorbed per milligram, often at a lower total fisetin dose.

Enhanced absorption and total dose are separate considerations. Double Wood’s formula provides a clearly disclosed 100 mg serving without a proprietary delivery blend.

Fisetin bioavailability can vary based on formulation and how it is taken. More human research is needed to determine how different delivery systems and dose levels compare for specific health outcomes.

What are senescent cells, and why does clearing them matter?

Senescent cells are stressed or damaged cells that have stopped dividing but remain active in the body. Some release inflammatory signals that can affect nearby healthy tissue and accumulate with age.

Senolytics are compounds being studied for their ability to selectively clear certain senescent cells. In a 2018 preclinical study, fisetin was the most potent senolytic among ten flavonoids tested and reduced markers of cellular senescence in mice and human tissue samples. These effects have not yet been established in humans taking fisetin supplements.

Overall rating: 4.875 / 5 from 40 reviews.

AI Generated Review Summary

Fisetin Supplement by Double Wood is praised for its high quality and beneficial effects on health, though opinions on its efficacy vary. It is soy-free, gluten-free, non-GMO, and vegan.

Summary topics

  • Supplement Quality (15%): A significant number of customers appreciated the supplement for its great quality and beneficial effects on their health.
  • Product Quality (18%): Many customers expressed satisfaction with the high quality of the supplement, praising its excellent quality and value.
  • Product Effect (20%): Opinions vary on the effect of the product, with some reporting no negative side effects.

Review topics: [improvement, quality, value, price, effect, supplement, fisetin, wood, health].

Review highlights

  • "High quality supplement." — Kamola M.
  • "I am impressed by the quality and price of Double Wood supplements, in particular, Fisetin." — Terri T.
  • "Good quality and value" — Gerard N.

Reviews

Great quality

"Great product!"

— Elisabete G. (5/5)

Fisetin

"I am impressed by the quality and price of Double Wood supplements, in particular, Fisetin. I am 67 years old and I definitely see an improvement in recalling details. My thinking is more clear."

— Terri T. (5/5)

Double Wood; THE best supplement company out there.

""Benefits of fisetin" There! I've put it in quotes, in order to make easy for you to look it up for yourself. From my point-of-view, it's one tremendous supplement, but don't take MY word for it. As for the company itself, there is none finer. If I absolutely must go to other websites for a supplement I will, but I'm never happy about it. For quality, testing, research, reasonable prices, efficacy, customer service and VERY fast shipping, you simply can't beat Double Wood."

— Alan B. (5/5)

Good quality and value

"Tested against other brands and Double Wood earned my trust on this one. Will be subscribing on this Fisetin."

— Gerard N. (5/5)

Great

"While I haven't noticed any improvements or changes after taking it for a month, I expect it's working because of what it is. My aim is to live healthier for longer. Fisetin, given all the research done on it will help. Obviously, try to get everything you need from food, but supplements do help. As an aside, I've looked at a lot of different companies and Double Wood seems legit. Supplements aren't cheap and I like to know that I'm getting what I'm paying for."

— Evan T. (5/5)

I would like to see

"I would like to see full bottles, with more capsules. It is silly to have such large bottles only say 1/3 full."

— judith K. (4/5)

Perfect!

"My doctor put me on this. It is working, I just take it 2 times per month. 7 in the am, and 7 in the pm. It works."

— Lisa K. (5/5)

Very good for me and

"Very good for me and my wife. High quality."

— MUKUNDKUMAR S. (5/5)

Fisetin

"I use three nootropic supplements from Double Wood: fisetin, alpha-gpc, and L-theanine. I also use other supplements and culinary herbs that may have related benefits (sage, rosemary, thyme, holy basil, green tea). So it is difficult to distinguish among effects."

— Robert B. (5/5)

High quality supplement. Love it

"High quality supplement. Love it"

— Kamola M. (5/5)

Q&A

Fisetin Supplement

From

$ 22.95

Primary Benefit

Antioxidants

Other Benefits

Healthy Aging

Product Form

Capsule
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