Spermidine Supplement

Spermidine trihydrochloride (3HCL) is the same molecule found naturally in food, produced by a controlled chemical process and verified by HPLC to 99% purity. The 3HCL form is the salt of spermidine paired with three hydrochloric acid molecules, which makes it water-soluble and shelf-stable — the same reason most prescription compounds use HCL salts. Spermidine 3HCL has been used in laboratory and clinical research for decades. The relevant safety question for any supplement is dose and purity, both of which are verified per batch by independent third-party testing and published in the disclosure table above.

Spermidine 3HCL is a purified single-compound supplement delivering a verified milligram dose. Wheat germ-derived spermidine is a plant extract that contains spermidine alongside other compounds, typically at concentrations under 1% by weight, meaning a 1,000mg wheat germ extract capsule may deliver as little as 1mg of spermidine. The 3HCL form delivers a precise, lab-verified dose without wheat or gluten. Wheat germ extract may include co-occurring polyamines (spermine, putrescine) but at variable concentrations between batches and brands. For users who need a verifiable dose, an allergen-free formula, or who want to track outcomes against a specific milligram amount, 3HCL is the more controllable form.

Every lot is tested by AILAB, an independent third-party laboratory, for four categories: identity (FTIR confirms the compound is spermidine 3HCL), potency (HPLC confirms percentage purity and mg per capsule), heavy metals (lead, cadmium, arsenic, mercury — tested against USP <232> limits), and microbial contamination (total plate count, yeast and mold, E. coli, Salmonella per USP <2021>/<2022>). Full results for the current lot and recent historical lots are published in the Batch-Level Potency & Purity Disclosure table on this page. The full PDF certificate is linked for each lot.

Most spermidine research in humans uses doses between 1.2mg and 6mg per day. Studies on cognitive aging have used 1.2mg per day for 12 weeks; some autophagy-focused protocols use 5–10mg per day. The European Food Safety Authority (EFSA) reviewed food-derived spermidine and identified 6mg per day as a safe daily intake. Double Wood's two-capsule serving delivers 10mg of spermidine 3HCL, which can be split across two doses if preferred. We recommend starting with one capsule (5mg) per day for the first week, then increasing to two capsules if well tolerated. Do not exceed four capsules (20mg) per day.

Yes. Double Wood's Spermidine is 99% pure spermidine trihydrochloride paired with rice flour and a plant cellulose (HPMC) capsule. It contains no wheat, gluten, soy, or animal-derived ingredients. Spermidine supplements derived from wheat germ extract or rice germ extract can trigger reactions in people with wheat, gluten, or grain allergies. If you have a known sensitivity to wheat or gluten and want spermidine's autophagy support, the 3HCL form is the safer choice.

Yes. Every batch is third-party tested by an ISO/IEC 17025-accredited laboratory for identity, spermidine content, heavy metals, and microbial safety. The active (Spermidine Trihydrochloride) is verified by HPLC against reference standards. The most recent COA covers Lot AILAB (reviewed 4/14/2026) with the full analytical panel: active assay, four heavy metals by ICP-MS (arsenic, cadmium, lead, mercury), and six microbial screens (Total Plate Count, Yeast & Mold, Coliform, E. coli, Salmonella, Staphylococcus aureus per USP and AOAC methods). Manufactured in a cGMP-certified U.S. facility from globally sourced ingredients.

The COA verifies identity and label-claim content of Spermidine Trihydrochloride per capsule by HPLC, with the synthetic ingredient form clearly disclosed. Heavy metals: arsenic, cadmium, lead, and mercury all below USP <2232> daily-intake limits by ICP-MS. Microbial results: Total Plate Count and Yeast & Mold within specification; Coliform, E. coli, Salmonella, and Staphylococcus aureus confirmed Absent or within USP limits. Lot AILAB is the most recent reviewed batch (4/14/2026); the current batch COA is linked above for verification against the lot number printed on your bottle.