Nattokinase Supplement

Nattokinase is a serine protease enzyme isolated from natto, a traditional Japanese food made from fermented soybeans. Dr. Hiroyuki Sumi discovered it in 1980 while screening clot-degrading compounds. Unlike most cardiovascular supplements that work upstream by improving vessel dilation or reducing inflammation, nattokinase works downstream through a process called fibrinolysis. It breaks down fibrin, the protein mesh that holds blood clots together. It also appears to inactivate plasminogen activator inhibitor-1 (PAI-1), the body’s own brake on clot dissolution.

Clinical research has shown nattokinase supplementation can reduce fibrinogen levels and modestly lower blood pressure in adults with elevated values. The evidence base is smaller than for pharmaceutical anticoagulants, and nattokinase is not a substitute for prescribed therapy. Its honest positioning is circulatory maintenance, supporting the fibrinolytic system the body already has.

Potency is measured in fibrin units (FU). Each capsule provides 2,000 FU per 100 mg. The two-capsule daily serving delivers 4,000 FU, matching the dose range used in published human trials. Every batch is tested for FU activity, identity, heavy metals, and microbial contaminants in an ISO/IEC 17025-accredited laboratory. Manufactured in a U.S. cGMP-certified facility from globally sourced ingredients. Vegan, gluten-free, non-GMO.

• Targets fibrin directly. Nattokinase is a fibrinolytic enzyme. It degrades fibrin already present in circulation rather than affecting upstream clotting factors. This is what makes its mechanism specific.
• Inhibits PAI-1. Plasminogen activator inhibitor-1 is the body’s brake on clot dissolution. By inactivating PAI-1, nattokinase helps the body’s natural fibrinolytic system work as designed.
• Clinically studied dose. Each serving provides 4,000 FU, within the range used in published human trials on cardiovascular markers and blood pressure.
• Verified FU activity. Every batch is tested for fibrin unit activity in an ISO/IEC 17025-accredited lab using a fibrin plate assay against reference enzyme standards.
• Manufactured to cGMP standard. Produced in a U.S. cGMP-certified facility from globally sourced ingredients. Vegan, gluten-free, non-GMO.

For use as a dietary supplement for cardiovascular health, we recommend taking two capsules per day (200 mg) with or without food. This dosage of our supplement provides 4000 FU of Nattokinase per day. We do not recommend exceeding this dosage.