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Nattokinase Supplement

$ 37.91

$ 39.90

Nattokinase is a powerful enzyme derived from fermented soybeans. It supports heart health and promotes healthy circulation for overall wellness.
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Description

Nattokinase is a serine protease enzyme isolated from natto, a traditional Japanese food made from fermented soybeans. Dr. Hiroyuki Sumi discovered it in 1980 while screening clot-degrading compounds. Unlike most cardiovascular supplements that work upstream by improving vessel dilation or reducing inflammation, nattokinase works downstream through a process called fibrinolysis. It breaks down fibrin, the protein mesh that holds blood clots together. It also appears to inactivate plasminogen activator inhibitor-1 (PAI-1), the body’s own brake on clot dissolution.


Clinical research has shown nattokinase supplementation can reduce fibrinogen levels and modestly lower blood pressure in adults with elevated values. The evidence base is smaller than for pharmaceutical anticoagulants, and nattokinase is not a substitute for prescribed therapy. Its honest positioning is circulatory maintenance, supporting the fibrinolytic system the body already has.


Potency is measured in fibrin units (FU). Each capsule provides 2,000 FU per 100 mg. The two-capsule daily serving delivers 4,000 FU, matching the dose range used in published human trials. Every batch is tested for FU activity, identity, heavy metals, and microbial contaminants in an ISO/IEC 17025-accredited laboratory. Manufactured in a U.S. cGMP-certified facility from globally sourced ingredients. Vegan, gluten-free, non-GMO.

Benefits
  • Targets fibrin directly. Nattokinase is a fibrinolytic enzyme. It degrades fibrin already present in circulation rather than affecting upstream clotting factors. This is what makes its mechanism specific.
  • Inhibits PAI-1. Plasminogen activator inhibitor-1 is the body’s brake on clot dissolution. By inactivating PAI-1, nattokinase helps the body’s natural fibrinolytic system work as designed.
  • Clinically studied dose. Each serving provides 4,000 FU, within the range used in published human trials on cardiovascular markers and blood pressure.
  • Verified FU activity. Every batch is tested for fibrin unit activity in an ISO/IEC 17025-accredited lab using a fibrin plate assay against reference enzyme standards.
  • Manufactured to cGMP standard. Produced in a U.S. cGMP-certified facility from globally sourced ingredients. Vegan, gluten-free, non-GMO.

Directions & Dosage

For use as a dietary supplement for cardiovascular health, we recommend taking two capsules per day (200 mg) with or without food. This dosage of our supplement provides 4000 FU of Nattokinase per day. We do not recommend exceeding this dosage.

View Latest Test Results

Third-party tested for quality and purity

This production lot was tested for nattokinase activity, capsule quality, heavy metals, and microbial quality

Test Claim or Limit Result
Potency
Nattokinase NLT 3,600 FU 3,853.96 FU
Physical Testing
Capsule Weight 223-247 mg 235 mg
Disintegration Time NMT 30 minutes Passed
Heavy Metals
Arsenic (As) ICP <10 µg/serving 0.085 µg/serving
Cadmium (Cd) ICP <4.1 µg/serving 0.005 µg/serving
Lead (Pb) ICP <0.5 µg/serving 0.118 µg/serving
Mercury (Hg) ICP <0.3 µg/serving 0.000 µg/serving
Microbial Testing
Total Plate Count <10,000 CFU/g <190 CFU/g
Total Yeast & Mold Count <1,000 CFU/g <19 CFU/g
E. Coli Absent Absent
Salmonella spp. Absent Absent
Staphylococcus aureus Absent Absent

Lot: 2604805Manufactured: 04/2026

Lab: Brand Nutraceuticals, Inc.

View Certificate of Analysis (PDF)

See the original Certificate of Analysis for complete testing details, methods, and laboratory documentation.
View Certificate of Analysis View Third Party Test Results

Every batch is manufactured in a cGMP facility and third-party tested for identity, potency, and contaminants including lead, cadmium, arsenic, and mercury.

Identity, potency, and contaminants verified per batch Identity, potency, and contaminants verified per batch
Manufactured in an FDA-registered cGMP facility Manufactured in an FDA-registered cGMP facility
Manufactured in the USA from Gloabally Sourced Materials Manufactured in the USA from Gloabally Sourced Materials

Benefits

  • CARDIOVASCULAR HEALTH - Nattokinase may help support a healthy circulatory system by lowering plasma levels of certain proteins that effect circulation
  • CIRCULATORY SUPPORT - Research suggests Nattokinase may help support cardiovascular health by promoting a healthy circulatory system
  • DERIVED FROM SOY (Japanese Natto) - Since Nattokinase is derived from fermented soybeans (Japanese Natto) there may be trace amounts of Soy in the product. Do not take if you are allergic to soy
  • TWO MONTH SUPPLY- Our Nattokinase supplement contains 60 servings of 200mg (4,000FU) which equals 120 Capsules (100mg 2,000 FU per capsule)
Benefits

Nattokinase

An enzyme extracted from the fermented soybean food natto. It is recognized in traditional wellness practices and modern nutrition. It is commonly chosen to supports healthy circulation and fibrin balance.

Nattokinase

What Customers Are Saying

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Supplement Facts

Pairs well with

Powerful alone, stronger together. Nattokinase Supplement delivers targeted support on its own, but combining it with complementary ingredients can help create a more holistic and balanced approach to wellness.

  • Magnesium Complex Supplement

    Magnesium Blend provides eight diverse forms of magnesium for balanced support, helping you feel your best every day.

  • Vitamin B Complex Drops

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Frequently Asked Questions

What does nattokinase do for the body?

Nattokinase is an enzyme that supports cardiovascular health by promoting healthy blood flow and helping to break down fibrin, a protein involved in blood clot formation. It may also aid in reducing blood pressure and improving overall circulation.

How much nattokinase should be taken per day?

The recommended daily dosage of nattokinase is typically 100 to 200 mg, providing around 2,000 to 4,000 fibrinolytic units (FU). It’s best to follow product guidelines and consult a healthcare provider for personalized advice.

How should nattokinase be taken, and when is the best time to take it?

Nattokinase should be taken on an empty stomach, either 30 minutes before meals or 2 hours after eating, to ensure optimal absorption. The best time to take it depends on personal routine, but many prefer morning or evening for consistency.

Why should nattokinase be taken on an empty stomach?

Nattokinase should be taken on an empty stomach to prevent interference from digestive enzymes and food, ensuring it remains active in the bloodstream to effectively support cardiovascular health and fibrin breakdown.

How long does nattokinase stay in your system?

Nattokinase typically stays active in the system for 8 to 12 hours, depending on individual metabolism and dosage. For consistent benefits, it’s often taken twice daily.

Is Double Wood Nattokinase third-party tested?

Yes. Every batch is third-party tested by an ISO/IEC 17025-accredited laboratory for identity, enzymatic activity, heavy metals, and microbial safety. Nattokinase activity is verified in fibrin units (FU) — the industry-standard measure of enzymatic potency — using a fibrin plate assay against reference standards. The full COA panel also covers four heavy metals via ICP-MS (arsenic, cadmium, lead, mercury against USP <2232> limits) and six microbial screens (Total Plate Count, Yeast & Mold, Coliform, E. coli, Salmonella, Staphylococcus aureus per USP and AOAC methods). Manufactured in a cGMP-certified U.S. facility from globally sourced ingredients.

What does the Nattokinase Certificate of Analysis confirm?

The COA verifies 2,000 FU (fibrin units) of nattokinase enzymatic activity per capsule, the dose used in published cardiovascular research on nattokinase. Activity is measured by fibrin plate assay against reference enzyme standards. Heavy metals: arsenic, cadmium, lead, mercury all below USP <2232> daily-intake limits by ICP-MS. Microbial counts within USP <2021>/<2022> specifications; E. coli, Salmonella, and Staphylococcus aureus confirmed Absent. The current batch COA is linked above for verification against your bottle's lot number.

Overall rating: 4.7941175 / 5 from 34 reviews.

AI Generated Review Summary

Summary topics

Review topics: ["quality","price"].

Review highlights

Reviews

"Love this stuff! Only wish it was dosed for 10,000FU. Everything im reading suggests this dose for BP deduction."

— Gilbert (5/5)

Good quality, fingers crossed

"After researching what Natto is and why it's good for you, I chose to take this brand, due to their results by third party testing. Only time will tell if it has a positive affect on my cardio system."

— Jill B. (4/5)

Nattokinase Supplement

"Arrived in a timely manner. Product quality looks good !"

— Dr E. (5/5)

Recommended for good health for

"Recommended for good health for the heart."

— Bernard K. (5/5)

Nattokinase

"Great product"

— Fred M. (5/5)

My doctor was amazed!

"I got the nattokinase, 4000FU I just wish it came in a larger dose as per the Chinese study ***pmc.ncbi.nlm.nih.***/articles/PMC9441630/ I upped my subscription to 3 bottles because I don't want to run out. I believe it's saving my life."

— Raymond W. (5/5)

My Cardiologist recommended this for

"My Cardiologist recommended this for my sticky blood."

— Mary C. (5/5)

"Came fast quality product"

— Corey (5/5)

Excellent Quality!

"Excellent quality!"

— Kim r. (5/5)

Fantastic!

"This has really been bringing my dad's blood pressure down. 🙏"

— Sam T. (5/5)

Q&A

I don&#x27;t have high BP..it runs normal but I do have high chlorestal. My concern is the lowering of my bp...how much does this lower??
Thank you for reaching out with your question! For faster assistance with product-related inquiries, we recommend contacting our customer service team directly at hello@doublewoodsupplements.com. Our team will be happy to provide the information or support you need.

Nattokinase Supplement

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$ 19.95

Primary Benefit

Heart & Vessels

Other Benefits

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