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NAD+ Supplement

$ 75.91

$ 79.90

NAD supports your body's natural processes, promoting overall vitality as you age. Keep your energy levels balanced with this essential supplement.
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Description

NAD+ — short for nicotinamide adenine dinucleotide — is a coenzyme found in every living cell and plays an important role in cellular energy metabolism, mitochondrial function, and many fundamental biological processes. NAD+ levels naturally decline with age, which is why many people look to NAD+ supplements or NAD+ precursor nutrients to support healthy aging and overall vitality.


Double Wood’s NAD+ Supplement provides 500 mg of direct NAD+ per serving and is made with >95% pure NAD+. This makes it a strong option for customers who want NAD+ itself rather than a precursor.


Prefer a precursor? Compare this formula with NMN, NMNH, or NR Malate to find the NAD+ support option that best fits your routine.


Soy-Free, Gluten-Free, Non-GMO, Vegan

Benefits
  • NAD BOOSTER: Supplementing with 95% pure NAD may help boost NAD levels as we age, making it an ideal longevity supplement
  • WHAT IS NAD?: NAD is an essential coenzyme found in all living cells. It is involved in many fundamental biological processes such as cell metabolism
  • NAD+ LEVELS FALL AS WE AGE: Since NAD+ levels decline as we age, supplementing with NAD can help support healthy aging, cognitive function, and immune system health
  • ROOTED IN QUALITY: Double Wood's NAD is manufactured right here in the USA from Globally Sourced Ingredients third party tested, Vegetarian, Non-GMO, and gluten-free
  • WE BOTTLE WELLNESS: At Double Wood we provide pure, potent supplements that deliver exceptional value, all backed by careful sourcing and rigorous third-party testing

Directions & Dosage

As a supplement for improved NAD+ levels, we recommend taking two capsules (1 serving, 500 mg) per day on an empty stomach. We don’t recommend exceeding the recommended dosage.

The Science Behind NAD+

NAD+ — nicotinamide adenine dinucleotide — is a coenzyme found in every living cell. It plays a central role in cellular energy metabolism, mitochondrial function, redox reactions, and NAD+-dependent enzymes involved in healthy aging pathways.

Research has shown that NAD+ biology is closely connected to sirtuins, a family of NAD+-dependent enzymes involved in metabolic regulation and cellular stress response. Foundational reviews by Imai & Guarente and Verdin helped establish NAD+ as an important molecule in aging, metabolism, and mitochondrial health research.

A broader review in Nature Reviews Molecular Cell Biology summarizes how NAD+ metabolism changes with age and how those changes may influence cellular processes such as DNA repair, mitochondrial function, immune regulation, and metabolic health (Covarrubias et al.).

Researchers have also studied NAD+ precursor nutrients such as nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN). In human and animal research, NR has been shown to increase markers of NAD+ metabolism after oral supplementation (Trammell et al.), while a randomized clinical study found that long-term NR supplementation was generally well tolerated in healthy overweight adults (Conze et al.).

A 2018 review in Cell Metabolism summarizes the broader in vivo evidence for NAD+-boosting molecules, including NR, NMN, nicotinamide, and related compounds (Rajman et al.). More recently, the 2026 NAD-brain pharmacokinetic study examined how oral NAD+ precursor supplementation influences NAD-related metabolites in blood and brain tissue, adding to the growing research around NAD+ augmentation strategies (Berven et al.).

Double Wood’s NAD+ Supplement provides direct NAD+ rather than a precursor nutrient. While much of the published human research focuses on NAD+ precursors like NR and NMN, the underlying science helps explain why customers compare direct NAD+, NMN, NMNH, and NR Malate when choosing an NAD+ support product.
View Certificate of Analysis View Third Party Test Results

Every batch is manufactured in a cGMP facility and third-party tested for identity, potency, and contaminants including lead, cadmium, arsenic, and mercury.

Identity, potency, and contaminants verified per batch Identity, potency, and contaminants verified per batch
Manufactured in an FDA-registered cGMP facility Manufactured in an FDA-registered cGMP facility
Manufactured in the USA from Gloabally Sourced Materials Manufactured in the USA from Gloabally Sourced Materials

Benefits

  • NAD Booster- Supplementing with 95% pure NAD may help boost NAD levels as we age making is an ideal longevity supplement
  • What is NAD? - NAD is an essential Coenzyme found in all living cells. It is involved in many fundamental biological processes such as cell metabolism
  • NAD+ Levels Fall as We Age - Research shows that NAD+ concentrations decline with age across multiple tissues, with aged tissue studies reporting decreases ranging from about 10–50% in liver and 15–65% in skeletal muscle (McReynolds, Chellappa & Baur). Because NAD+ plays an important role in cellular energy metabolism, mitochondrial function, and NAD+-dependent enzymes, maintaining healthy NAD+ metabolism has become a major focus in healthy-aging research.

Benefits

NAD+

NAD+ is a central cellular coenzyme involved in energy metabolism and normal mitochondrial function. Double Wood’s NAD+ Supplement provides 500 mg of NAD+ per serving, delivered as 2 capsules.

NAD+

What Customers Are Saying

Reviews

"Reputation of product and overall delivery and ordering experience has always been a good experience."

Jacqueline P.

"Always fast shipping and great selection no matter what you’re looking for."

Aaron B.

"Double Wood is always my go-to for supplements. Great, effective, clean products and always at a reasonable price."

Jan W.

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Reviews
Supplement Facts

NAD+ vs. NMN vs. NMNH - which one is right for you?

If you're new to NAD+ supplementation, the question isn't whether to support your NAD+ levels - it's where in the pathway to start. Each one enters the salvage pathway at a different point, has a different evidence base, and suits a different type of user. Here's how they compare.

Scroll to compare →

COMPARE NAD+ NMN NMNH
WHAT IT IS in one sentence

The end-stage coenzyme itself — the molecule every cell uses for energy production, DNA repair, and sirtuin activation.

A direct precursor to NAD+ — one enzymatic step away from the active coenzyme.

The reduced (hydrogenated) form of NMN, formulated for greater stability and a longer NAD+-elevation window.
WHERE IT SITS on the salvage pathway

The destination. NAD is what NMN, NMNH, and NR are all converted into inside the cell.

One step upstream of NAD+. Converted via NMNAT enzymes once it reaches the cytoplasm.

Same step as NMN, but enters in a reduced state — research suggests this changes how it's processed and how long it stays elevated.
BIOAVAILABILITY PROFILE what we know

Direct oral NAD is partially broken down in digestion before reaching cells. The mechanism by which oral NAD raises tissue NAD+ is debated in the literature — most likely via downstream salvage intermediates.

Rapidly absorbed orally; short half-life, which is why split-dosing (morning + afternoon) is recommended. A 2026 head-to-head trial in iScience measured a 67% rise in blood NAD+ at a 1,200 mg dose.

Preclinical data suggests NMNH produces higher and longer-lasting NAD+ elevation than standard NMN — though most of this evidence is from animal studies, not yet replicated in published human trials.
CLINICAL EVIDENCE human data summary

Sparse. Most published human research in the NAD space is on the precursors (NR and NMN), not on direct oral NAD as a finished supplement. Mechanism studies dominate the literature.

Multiple human pharmacokinetic trials. Some product-level studies on branded forms (e.g. Uthever). The 2026 iScience crossover is the most recent peer-reviewed comparison.

Mostly preclinical and early-stage. The often-quoted figures comparing NMNH to NMN come from animal studies — promising signal, but not yet validated by published human RCTs.
TYPICAL DAILY DOSE Double Wood serving

500 mg / day  (2 caps × 250 mg)

Taken on an empty stomach, in the morning.

250 mg / day  (2 caps × 125 mg)

Split-dosed: one capsule on waking, one in the afternoon.

250 mg / day  (2 caps)

Taken on an empty stomach.
BEST FOR who picks this

Customers who want to supplement the active coenzyme directly, often as a complement to a precursor protocol. Lowest barrier to entry at $1.33 per serving.

Longevity-focused users following Sinclair-style protocols, or anyone wanting the most-studied direct precursor. Strongest fit for split-dosing routines.

Early-adopters who track longevity research closely and want the newest, most-stable NMN form. A reasonable next step for users not satisfied with standard NMN.
SHOP View NAD+ → View NMN → View NMNH →

Still not sure? A reasonable rule of thumb: If you want the most-discussed direct precursor in longevity protocols, start with NMN. If you want the newest NMN form with promising preclinical data, NMNH is the early-adopter pick.

Pairs well with

Powerful alone, stronger together. NAD+ Supplement delivers targeted support on its own, but combining it with complementary ingredients can help create a more holistic and balanced approach to wellness.

  • Resveratrol Supplement

    Resveratrol offers antioxidant support and is found in grapes and wine, contributing to your wellness journey.

  • TMG Supplement

    Trimethylglycine (TMG) supports your overall well-being, helping to maintain healthy levels in your body. It's a great addition to your daily routine.

Frequently Asked Questions

What is NAD+?

NAD+ (nicotinamide adenine dinucleotide) is a vital coenzyme found in every cell of the body, playing a critical role in energy production and cellular repair. It supports metabolism, DNA repair, and healthy aging processes.

Why do NAD+ levels matter as we age?

NAD+ plays a central role in redox reactions, mitochondrial function, cellular energy metabolism, DNA repair pathways, and NAD+-dependent enzymes such as sirtuins and PARPs. Research reviews have reported that NAD+ metabolism changes with age and may influence cellular processes connected to healthy aging. This does not mean NAD+ supplements treat or prevent age-related disease, but it explains why NAD+ support has become a major area of longevity research.

How much NAD+ should I take per day?

The recommended daily serving is 2 capsules per day, which provides 500 mg of NAD+. Take it on an empty stomach, preferably in the morning, and do not exceed the recommended dosage unless directed by a healthcare professional.

Taking NAD+ in the morning aligns with when many people prefer to support energy metabolism, while taking it on an empty stomach may help reduce competition with food during digestion. Some people choose to split their serving between morning and early afternoon, but the product’s standard serving is 2 capsules daily.

What’s the difference between NAD, NAD+, NMN, NR, and NMNH?

NAD+ is the active oxidized form of nicotinamide adenine dinucleotide, a coenzyme involved in cellular energy metabolism. NAD is often used as a general shorthand for the NAD family. NMN, NR, and NMNH are precursor nutrients or related compounds that the body can use in NAD+ metabolism. Double Wood’s NAD+ Supplement provides direct NAD+, while NMN, NMNH, and NR Malate are different options for people who prefer precursor-based NAD+ support.

What are the side effects of NAD+ supplements?

NAD+ supplements are generally well-tolerated, but some individuals may experience mild side effects such as nausea, headaches, fatigue, or digestive discomfort. Always consult a healthcare provider if side effects persist or worsen.

Is Double Wood NAD+ third-party tested?

Yes. Every batch is third-party tested by an ISO/IEC 17025-accredited laboratory for identity, potency, heavy metals, and microbial safety. The active assay (Nicotinamide Adenine Dinucleotide) is verified by HPLC against reference standards. The full COA panel covers four heavy metals (arsenic, cadmium, lead, mercury by ICP-MS against USP <2232> limits) and six microbial screens (Total Plate Count, Yeast & Mold, Coliform, E. coli, Salmonella, Staphylococcus aureus per USP <2021>/<2022> and AOAC methods). Manufactured in a cGMP-certified U.S. facility from globally sourced ingredients.

What does the NAD+ Certificate of Analysis confirm?

The COA verifies identity and content of Nicotinamide Adenine Dinucleotide per capsule by HPLC, with the active assay meeting label claim. Heavy metals: arsenic, cadmium, lead, and mercury all verified below USP <2232> daily-intake limits via ICP-MS. Microbials: Total Plate Count and Yeast & Mold within specification; E. coli, Salmonella, and Staphylococcus aureus confirmed Absent. The current batch COA is linked above for verification against the lot number on your bottle.

Overall rating: 5.0 / 5 from 17 reviews.

AI Generated Review Summary

Summary topics

Review topics: [quality, term, supplement].

Review highlights

Reviews

Feeling younger everyday! 🤩

"Great product from an amazing company! Love the clean supplements! Price is a bonus too!"

— Anthony O. (5/5)

Good supplement

"This is a good supplement with a nutritious diet to keep your energy up."

— Robert S. (5/5)

I haven't felt much different.

"It hasn't been a month yet. Hoping it will kick in soon I have read the liquid goes into your system quicker is there any truth to this?"

— Marcia A. (5/5)

Excellent Quality

"Quality product, good packaging, consistent product, long term daily maintenance."

— Aaron K. (5/5)

I rarely see obvious benefits right away. . .

"As a chemist and biologist, I am intrigued by the theoretical benefits of many supplements but typically find that I can see no real changes -- short term or long term. Of course, if longevity is the long-term goal, I suppose we have to wait for the review from the afterlife, but these seem to provide me with more energy to complete more tasks in my hectic 365-day work year."

— Stephen G. (5/5)

"Excellent"

— Mark (5/5)

"Awesome product"

— Ivan (5/5)

"Very good"

— John (5/5)

Doing well

"So far so good. It's only been a week but I've tolerated this week without bad side effects and that's a big deal for me. I've noticed an increase on energy and have not required coffee! That alone in such a short time is wonderful!!"

— Abigail (5/5)

Seems to be good quality

"Recommended by my healthcare provider. I'm happy with the quality."

— Hannah O. (5/5)

Q&A

Is it ok to break open the capsules and put in water to drink instead of swallowing the capsules?
Yes, it is generally safe to break open NAD+ (nicotinamide adenine dinucleotide) capsules and mix the contents with water. However, mixing the contents with water could result in faster absorption, but it may also lead to degradation as the product is sensitive to light, moisture, and air.
Double Wood NAD+ supplement bottle, 60 capsules, 500mg per serving

NAD+ Supplement

From

$ 39.95

Primary Benefit

Healthy Aging

Other Benefits

Product Form

Capsule
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